The Objective Structured Clinical Examination is an essential tool for the assessment of the clinical skills of health professionals. One of the most significant parts of OSCE includes role-playing in simulated scenarios, where candidates interact with standardized patients, such as actors portraying patients, to demonstrate their ability to perform various clinical tasks. Therefore, by honing your role-playing skills, you can enhance your confidence and increase your chances of success during this crucial exam. Here is an insight into how practical OSCE role plays, techniques and methods for performing at an excellent level in these simulation exams can help you ace the OSCE.